Actimetrics

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References

A sampling of  over 2000 papers that have made use of Actimetrics systems.

FreezeFrame    WaterMaze   LimeLight    ClockLab    LumiCycle     MultiCycle

FreezeFrame

Takashi Kitamura, Sachie K. Ogawa, Dheeraj S. Roy, Teruhiro Okuyama, Mark D. Morrissey, Lillian M. Smith, Roger L. Redondo, Susumu Tonegawa (2017) Engrams and circuits crucial for systems consolidation of a memory. Science 6333:73-78.

Dheeraj S. Roy, Autumn Arons, Teryn I. Mitchell, Michele Pignatelli, Tomás J. Ryan, Susumu Tonegawa (2016) Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease. Nature 531,508–512.

Tomás J. RyanDheeraj S. Roy, Michele Pignatelli, Autumn Arons, Susumu Tonegawa (2015) Engram cells retain memory under retrograde amnesia. Science 6238:1007-1013

Ainsley, J.A., Drane, L., Jacobs, J., Kittelberger, K.A., and Reijmers, L.G. (2014). Functionally diverse dendritic mRNAs rapidly associate with ribosomes following a novel experience. Nature communications 5, 4510.

Liu, C.C., Tsai, C.W., Deak, F., Rogers, J., Penuliar, M., Sung, Y.M., Maher, J.N., Fu, Y., Li, X., Xu, H., et al. (2014). Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer’s disease. Neuron 84, 63-77.

Jahrling, J.B., Hernandez, C.M., Denner, L., and Dineley, K.T. (2014). PPARgamma recruitment to active ERK during memory consolidation is required for Alzheimer’s disease-related cognitive enhancement. Journal of neuroscience 34, 4054-4063.

Heckman, L.D., Chahrour, M.H., and Zoghbi, H.Y. (2014). Rett-causing mutations reveal two domains critical for MeCP2 function and for toxicity in MECP2 duplication syndrome mice. eLife 3:e02676

Chen, T., Lu, J.S., Song, Q., Liu, M.G., Koga, K., Descalzi, G., Li, Y.Q., and Zhuo, M. (2014). Pharmacological rescue of cortical synaptic and network potentiation in a mouse model for fragile X syndrome. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 39, 1955-1967.

Gomez, A.M., Froemke, R.C., and Burden, S.J. (2014). Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4. eLife 3:e04287.

Ramirez S, Liu X, Lin PA, Suh J, Pignatelli M, Redondo RL, Ryan TJ, Tonegawa S. (2013). Creating a false memory in the hippocampus. Science 341:387-91.

Trouche S1, Sasaki JM, Tu T, Reijmers LG. (2013) Fear extinction causes target-specific remodeling of perisomatic inhibitory synapses. Neuron. 80:1054-65.

Parkhurst CN, Yang G, Ninan I, Savas JN, Yates JR, Lafaille JJ, Hempstead BL, Littman DR, Gan WB. (2013) Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell. 155:1596-1609.

A. S. Sengar, J. Ellegood, A. P. Yiu, H. Wang, W. Wang, S. C. Juneja, J. P. Lerch, S. A. Josselyn, R. M. Henkelman, M. W. Salter, and S. E. Egan (2103) Vertebrate Intersectin1 Is Repurposed to Facilitate Cortical Midline Connectivity and Higher Order Cognition The Journal of Neuroscience 33: 4055-4065.

Qi Shi, Marguerite Prior, Xiangdong Zhou, Xiaoying Tang, Wanxia He, Xiangyou Hu, and Riqiang Yan (2013) Preventing Formation of Reticulon 3 Immunoreactive Dystrophic Neurites Improves Cognitive Function in Mice. The Journal of Neuroscience 33: 3059-3066.

Carmelina Gemma, Matthew Fister, Charles Hudson, Paula C. Bickford (2013) Improvement of memory for context by inhibition of caspase-1 in aged rats. European Journal of Neuroscience22:1751–1756.

Miho Terunuma, Raquel Revilla-Sanchez, Isabel M. Quadros, Qiudong Deng, Tarek Z. Deeb, Michael Lumb, Piotr Sicinski, Philip G. Haydon, Menelas N. Pangalos, and Stephen J. Moss (2013) Postsynaptic GABAB Receptor Activity Regulates Excitatory Neuronal Architecture and Spatial Memory The Journal of Neuroscience 34: 804-816.

Liu, X., Ramirez, S., Pang, P.T., Puryear, C.B., Govindarajan, A., Deisseroth, K., and Tonegawa, S. (2012). Optogenetic stimulation of a hippocampal engram activates fear memory recall.Nature 484, 381-385.

Lugo, J.N., Brewster, A.L., Spencer, C.M., and Anderson, A.E. (2012). Kv4.2 knockout mice have hippocampal-dependent learning and memory deficits. Learning and Memory 19:182-189.

Song, C., Detert, J.A., Sehgal, M., and Moyer, J.R., Jr. (2012). Trace fear conditioning enhances synaptic and intrinsic plasticity in rat hippocampus. Journal of Neurophysiology 107:3397-3408.

Akers, K.G., Arruda-Carvalho, M., Josselyn, S.A., and Frankland, P.W. (2012). Ontogeny of contextual fear memory formation, specificity, and persistence in mice.Learning and Memory19, 598-604.

Kheirbek, M.A., Tannenholz, L., and Hen, R. (2012). NR2B-dependent plasticity of adult-born granule cells is necessary for context discrimination. Journal of Neuroscience 32:8696-8702.

Tanokashira, D., Morita, T., Hayashi, K., Mayanagi, T., Fukumoto, K., Kubota, Y., Yamashita, T., and Sobue, K. (2012). Glucocorticoid suppresses dendritic spine development mediated by down-regulation of caldesmon expression. J Neurosci 32, 14583-14591.

Kleschevnikov, A.M., Belichenko, P.V., Faizi, M., Jacobs, L.F., Htun, K., Shamloo, M., and Mobley, W.C. (2012). Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists. J Neurosci 32, 9217-9227.

Elder, G.A., Dorr, N.P., De Gasperi, R., Gama Sosa, M.A., Shaughness, M.C., Maudlin-Jeronimo, E., Hall, A.A., McCarron, R.M., and Ahlers, S.T. (2012). Blast exposure induces post-traumatic stress disorder-related traits in a rat model of mild traumatic brain injury. Journal of Neurotrauma 29, 2564-2575.

Lai, C.S., Franke, T.F., and Gan, W.B. (2012). Opposite effects of fear conditioning and extinction on dendritic spine remodelling. Nature 483, 87-91.

Parker, C.C., Sokoloff, G., Cheng, R., and Palmer, A.A. (2012). Genome-wide association for fear conditioning in an advanced intercross mouse line. Behavior Genetics 42, 437-448.

Sahay, A., Scobie, K.N., Hill, A.S., O’Carroll, C.M., Kheirbek, M.A., Burghardt, N.S., Fenton, A.A., Dranovsky, A., and Hen, R. (2011). Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature 472, 466-470.

John J. Perkowski and Geoffrey G. Murphy (2011) Deletion of the Mouse Homolog of KCNAB2, a Gene Linked to Monosomy 1p36, Results in Associative Memory Impairments and Amygdala Hyperexcitability. Journal of Neuroscience 31:46-54.

Luke W Ayers, Galen Missig, Jay Schulkin and Jeffrey B Rosen (2011) Oxytocin Reduces Background Anxiety in a Fear-Potentiated Startle Paradigm: Peripheral vs Central AdministrationNeuropsychopharmacology (epub).

Kimberly N. Scobie, Benjamin J. Hall, Scott A. Wilke, Kristen C. Klemenhagen, Yoshiaki Fujii-Kuriyama, Anirvan Ghosh, René Hen and Amar Sahay (2011) Krüppel-Like Factor 9 Is Necessary for Late-Phase Neuronal Maturation in the Developing Dentate Gyrus and during Adult Hippocampal Neurogenesis. Journal of Neuroscience 29:9875-9887.

Caterina M. Hernandez, Rakez Kayed, Hui Zheng, J. David Sweatt, and Kelly T. Dineley (2010) Loss of α7 Nicotinic Receptors Enhances β-Amyloid Oligomer Accumulation, Exacerbating Early-Stage Cognitive Decline and Septohippocampal Pathology in a Mouse Model of Alzheimer’s Disease. Journal of Neuroscience 30:2442–2453.

Laleh Sinai, Steven Duffy and John C. Roder (2010) Src inhibition reduces NR2B surface expression and synaptic plasticity in the amygdala. Learning and Memory 17:364-371.

Yair Shemesh, Ada Eban-Rothschild, Mira Cohen, and Guy Bloch (2010) Molecular Dynamics and Social Regulation of Context-Dependent Plasticity in the Circadian Clockwork of the Honey Bee. Journal of Neuroscience 30:12517-12525.

Yu Ohmura, Takeshi Izumi, Taku Yamaguchi, Iku Tsutsui-Kimura, Takayuki Yoshida and Mitsuhiro Yoshioka (2010) The Serotonergic Projection from the Median Raphe Nucleus to the Ventral Hippocampus is Involved in the Retrieval of Fear Memory Through the Corticotropin-Releasing Factor Type 2 Receptor. Neuropsychopharmacology 35:1271–1278.

Ji Y Lee, Patricio T Huerta, Jie Zhang, Czeslawa Kowal, Eva Bertini, Bruce T Volpe & Betty Diamond (2009) Neurotoxic autoantibodies mediate congenital cortical impairment of offspring in maternal lupus. Nature Medicine 15:91-96.

Viviane Labrie, Steven Duffy, Wei Wang, Steven W. Barger, Glen B. Baker and John C. Roder (2009) Genetic inactivation of D-amino acid oxidase enhances extinction and reversal learning in mice. Learning and Memory 16:28-37.

Wataru Ito, Bing-Xing Pan, Chao Yang, Siddarth Thakur and Alexei Morozov (2009) Enhanced generalization of auditory conditioned fear in juvenile mice. Learning and Memory 16:187-192.

Bridget M. McKay, Elizabeth A. Matthews, Fernando A. Oliveira, and John F. Disterhoft (2009) Intrinsic Neuronal Excitability Is Reversibly Altered by a Single Experience in Fear Conditioning. Journal of Neurophysiology 102:2763-2770.

J-.H. Han, S. A. Kushner, A. P. Yiu, H-.L. Hsiang, T. Buch, A. Waisman, B. Bontempi, R.L. Neve, P.W. Frankland, and S. A. Josselyn (2009) Selective Erasure of a Fear Memory. Science 13: 323:1492-1496.

Daniela D. Pollak,Francisco J. Monje,Lee Zuckerman, Christine A. Denny, Michael R. Drew and Eric R. Kandel (2008) An Animal Model of a Behavioral Intervention for Depression. Neuron60:149-161.

Brandon C. McKinney, Wilson Sze, Jessica A. White, and Geoffrey G. Murphy (2008) L-type voltage-gated calcium channels in conditioned fear: A genetic and pharmacological analysis.Learning and Memory 15: 326-334

Ji Y Lee, Patricio T Huerta, Jie Zhang, Czeslawa Kowal, Eva Bertini, Bruce T Volpe and Betty Diamond (2008) Neurotoxic autoantibodies mediate congenital cortical impairment of offspring in maternal lupus. Nature Medicine 15:91 – 96.

Robert Waltereit, Sönke Mannhardt, Sabine Nescholta, Christiane Maser-Gluth, and Dusan Bartsch (2008) Selective and protracted effect of nifedipine on fear memory extinction correlates with induced stress response. Learning and Memory 15:348-356.

Bing-Xing Pan, Francois Vautier, Wataru Ito, Vadim Y. Bolshakov, and Alexei Morozov (2008) Enhanced Cortico-Amygdala Efficacy and Suppressed Fear in Absence of Rap1. Journal of Neuroscience 28:2089-2098.

Albert Y. Hung, Kensuke Futai, Carlo Sala, Juli G. Valtschanoff, Jubin Ryu, Mollie A. Woodworth, Fleur L. Kidd, Clifford C. Sung, Tsuyoshi Miyakawa, Mark F. Bear, Richard J. Weinberg, and Morgan Sheng (2008) Smaller Dendritic Spines, Weaker Synaptic Transmission, but Enhanced Spatial Learning in Mice Lacking Shank1. Journal of Neuroscience 28:1697–1708.

Naoki Matsuo, Leon Reijmers, Mark Mayford (2008) Spine-Type Specific Recruitment of Newly Synthesized AMPA Receptors with Learning. Science 319: 1104-1107.

Leon G. Reijmers, Brian L. Perkins, Naoki Matsuo, Mark Mayford (2007) Localization of a Stable Neural Correlate of Associative Memory Science 317:1230-1233.

T.J. Kotti, D.M.O. Ramirez, B.E. Pfeiffer, K.M. Huber and D.W. Russell (2006) Brain cholesterol turnover required for geranylgeraniol production and learning in mice. PNAS 103:3869-3847.

M.D. Saxe, F. Battaglia, J.-W. Wang, G. Malleret, D.J. David, J.E. Monckton, A.D.R. Garcia, M.V. Sofroniew, E.R. Kandel, Luca Santarelli, R. Hen and M.R. Drew (2006) Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. PNAS 103:17501-17506.

S. Shalin, C. Hernandez, M. Dougherty, D. Morrison, J. Sweatt (2006) Kinase Suppressor of Ras1 Compartmentalizes Hippocampal Signal Transduction and Subserves Synaptic Plasticity and Memory Formation. Neuron, 50:765-779.

J.M. Long, P. LaPorte, S. Merscher, B. Funke, B. Saint-Jore, A. Puech, R. Kucherlapati, B.E. Morrow, A.I. Skoultchi and A. Wynshaw-Boris (2006) Behavior of mice with mutations in the conserved region deleted in velocardiofacial/DiGeorge syndrome. Neurogenetics, 7:247-257.

B.C. McKinney and G.G. Murphy (2006) The L-Type voltage-gated calcium channel Cav1.3 mediates consolidation, but not extinction, of contextually conditioned fear in mice. Learning and Memory, 13:584-589.

C.A. Saura, G. Chen, S. Malkani, S.-Y. Choi, R.H. Takahashi, D. Zhang, G.K. Gouras, A. Kirkwood, R.G.M. Morris and J. Shen (2006) Conditional Inactivation of Presenilin 1 Prevents Amyloid Accumulation and Temporarily Rescues Contextual and Spatial Working Memory Impairments in Amyloid Precursor Protein Transgenic Mice. Journal of Neuroscience, 25:6755– 6764.

L.G. Reijmers, J.K. Coats, M.T. Pletcher, T. Wiltshire, L.M. Tarantino and M. Mayford (2006) A mutant mouse with a highly specific contextual fear-conditioning deficit found in an N-ethyl-N-nitrosourea (ENU) mutagenesis screen. Learning and Memory13:143-149

Gleb P. Shumyatsky, Gaël Malleret, Ryong-Moon Shin, Shuichi Takizawa, Keith Tully, Evgeny Tsvetkov, Stanislav S. Zakharenko, Jamie Joseph, Svetlana Vronskaya, DeQi Yin, Ulrich K. Schubart, Eric R. Kandel, and Vadim Y. Bolshakov, (2005) stathmin, A gene enriched in the amygdala, controls both learned and innate fear Cell, 123:697-709.

Leon G. Reijmers, Jennifer K. Coats, Mathew T. Pletcher, Tim Wiltshire, Lisa M. Tarantino and Mark Mayford (2006) A mutant mouse with a highly specific contextual fear-conditioning deficit found in an N-ethyl-N-nitrosourea (ENU) mutagenesis screen. Learning and Memory 13:143-149.

Saura CA, Choi SY, Beglopoulos V, Malkani S, Zhang D, Shankaranarayana Rao BS, Chattarji S, Kelleher RJ 3rd, Kandel ER, Duff K, Kirkwood A, Shen J. (2005) Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration.Neuron 42:23-36.

Michelle L. Gottsch, Hongkui Zeng, John G. Hohmann, David Weinshenker, Donald K Clifton, and Robert A. Steiner (2005) Phenotypic Analysis of Mice Deficient in the Type 2 Galanin Receptor (GALR2). Molecular and Cellular Biology 25:4804-4811

Carlos A. Saura, Guiquan Chen, Seema Malkani, Se-Young Choi, Reisuke H. Takahashi, Dawei Zhang, Gunnar K. Gouras, Alfredo Kirkwood, Richard G. M. Morris and Jie Shen (2005) Conditional Inactivation of Presenilin 1 Prevents Amyloid Accumulation and Temporarily Rescues Contextual and Spatial Working Memory Impairments in Amyloid Precursor Protein Transgenic Mice Journal of Neuroscience 25:6755-6764

X Zhou, J M Long, M A Geyer, E Masliah, J R Kelsoe, A Wynshaw-Boris, K R Chien (2005) Reduced expression of the Sp4 gene in mice causes deficits in sensorimotor gating and memory associated with hippocampal vacuolization. Molecular Psychiatry 10:393-406.

MG Zhao, H Toyoda, SW Ko, HK Ding, LJ Wu, M Zhuo (2005) Deficits in Trace Fear Memory and Long-Term Potentiation in a Mouse Model for Fragile. Journal of Neuroscience 25: 7385-7392.

Kiyohiko Angata, Jeffrey M. Long, Olena Bukalo, Wenjau Lee, Alexander Dityatev, Anthony Wynshaw-Boris, Melitta Schachner, Minoru Fukuda|, and Jamey D. Marth (2004) Sialyltransferase ST8Sia-II Assembles a Subset of Polysialic Acid That Directs Hippocampal Axonal Targeting and Promotes Fear Behavior. J. Biol. Chem., 279:32603-32613.

Mesches, M.H., Gemma, C., Veng, L.M., Allgeier, C., Young, D.A., Browning, M.D. and Bickford, P.C. (2004) Sulindac improves memory and increases NMDA receptor subunits in aged Fischer 344 rats. Neurobiology of Aging 25:315-324.

Korzus, E., Rosenfeld, M.G. and Mayford, M (2004) CBP Histone Acetyltransferase Activity Is a Critical Component of Memory Consolidation. Neuron 42:961-972.

Mark D. Lindner, Donald B. Hodges, Jr., John B. Hogan, Anitra F. Orie, Jason A. Corsa, Donna M. Barten, Craig Polson, Barbara J. Robertson, Valerie L. Guss, Kevin W. Gillman, John E. Starrett, Jr., and Valentin K. Gribkoff (2003) An Assessment of the Effects of Serotonin 6 (5-HT6) Receptor Antagonists in Rodent Models of Learning. Journal of Pharmacology And Experimental Therapeutics 307:682-691.

Miller S, Yasuda M, Coats JK, Jones Y, Martone ME, Mayford M. (2002) Disruption of dendritic translation of CaMKIIalpha impairs stabilization of synaptic plasticity and memory consolidation.Neuron 36:507-19.


WaterMaze (Top)

Zhong-Hao Zhang, Qiu-Yan Wu, Rui Zheng, Chen Chen, Yao Chen, Qiong Liu, Peter R. Hoffmann, Jia-Zuan Ni and Guo-Li Song (2017) Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer’s Disease Mouse Model. Journal of Neuroscience 37:2449-2462.

S. Caughey, A. P. Harris, J. R. Seckl, M. C. Holmes, and J. L. W. Yau (2017) Forebrain-Specific Transgene Rescue of 11β-HSD1 Associates with Impaired Spatial Memory and Reduced Hippocampal Brain-Derived Neurotrophic Factor mRNA Levels in Aged 11β-HSD1 Deficient Mice. Journal of Neuroendocrinology 29 (online).

Pooneh Memar Ardestani, Andrew K. Evans, Bitna Yi, Tiffany Nguyen, Laurence Coutellier1, and Mehrdad Shamlo (2017) Modulation of neuroinflammation and pathology in the 5XFAD mouse model of Alzheimer’s disease using a biased and selective beta-1 adrenergic receptor partial agonist. Neuropharmacology 116:371–386.

Fatima A. Nasrallaha, Xuan Vinh Toa, Der-Yow Chenb, Aryeh Routtenbergc, Kai-Hsiang Chuanga (2016) Functional connectivity MRI tracks memory networks after maze learning in rodents, NeuroImage 127:196–202.

Xiaofeng XuBin ZhangKaili LuJiangshan DengFei ZhaoBing-qiao ZhaoYuwu Zhao (2016) Prevention of Hippocampal Neuronal Damage and Cognitive Function Deficits in Vascular Dementia by Dextromethorphan. MolecularNeurobiology 53, 3494–3502.

Axel Guskjolena, Sheena A. Josselyna, Paul W. Franklanda Age-dependent changes in spatial memory retention and flexibility in mice. Neurobiology of Learning and Memory

Petrella, L. I., Cai, Y., Sereno, J. V., Gonçalves, S. I., Silva, A. J. and Castelo-Branco, M. (2016), Brain and behaviour phenotyping of a mouse model of neurofibromatosis type-1: an MRI/DTI study on social cognition. Genes, Brain and Behavior 15: 637–646.

Karen Sooy, June Noble, Andrew McBride, Margaret Binnie, Joyce L. W. Yau, Jonathan R. Seckl, Brian R. Walker, and Scott P. Webster (2015) Cognitive and Disease-Modifying Effects of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer’s Disease. Endocrinology 156: 4592-4603.

Harland, Bruce; Wood, Emma R.; Dudchenko, Paul A. (2015) The head direction cell system and behavior: The effects of lesions to the lateral mammillary bodies on spatial memory in a novel landmark task and in the water maze. Behavioral Neuroscience 129:709-719.

David Pritchett, Amy M Taylor, Christopher Barkus, Sandra J Engle, Nicholas J Brandon, Trevor Sharp, Russell G Foster, Paul J Harrison, Stuart N Peirson, David M Bannerman (2016) Searching for cognitive enhancement in the Morris water maze: better and worse performance in D-amino acid oxidase knockout (Dao−/−) mice. Journal of European Neuroscience 43:979–989.

Morris, Richard G. M. (2014) The Watermaze. In The Maze Book: Theories, Practice, and Protocols for Testing Rodent Cognition
Editor: H. A.Bimonte-Nelson. Springer, New York, New York, NY

Lee, Y.S., Ehninger, D., Zhou, M., Oh, J.Y., Kang, M., Kwak, C., Ryu, H.H., Butz, D., Araki, T., Cai, Y., et al. (2014). Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome. Nature Neuroscience 17, 1736-1743.

Richards, B.A., Xia, F., Santoro, A., Husse, J., Woodin, M.A., Josselyn, S.A., and Frankland, P.W. (2014). Patterns across multiple memories are identified over time. Nature Neuroscience 17, 981-986.

de Hoz, L., and Martin, S.J. (2014). Double dissociation between the contributions of the septal and temporal hippocampus to spatial learning: the role of prior experience. Hippocampus 24, 990-1005.

Bruno M. da Silva, Tobias Bast, and Richard G.M. Morris (2013) Spatial memory: behavioral determinants of persistence in the watermaze delayed matching-to-place task. Learning and Memory 21: 28-36.

A. S. Sengar, J. Ellegood, A. P. Yiu, H. Wang, W. Wang, S. C. Juneja, J. P. Lerch, S. A. Josselyn, R. M. Henkelman, M. W. Salter, and S. E. Egan (2103) Vertebrate Intersectin1 Is Repurposed to Facilitate Cortical Midline Connectivity and Higher Order Cognition. The Journal of Neuroscience, 33: 4055-4065.

G. I. Cancino, A. P. Yiu, M. P. Fatt, C. B. Dugani1, E. R. Flores, P. W. Frankland, S. A. Josselyn,F . D. Miller, and D. R. Kaplan (2013) p63 Regulates Adult Neural Precursor and Newly Born Neuron Survival to Control Hippocampal-Dependent Behavior Journal of Neuroscience33:12569-12585.

Alonso Martinez-Canabal, Katherine G. Akers, Sheena A. Josselyn, Paul W. Frankland (2013) Age-dependent effects of hippocampal neurogenesis suppression on spatial learning.Hippocampus 23:66–74.

Kotermanski SE1, Johnson JW, Thiels (2013) Comparison of behavioral effects of the NMDA receptor channel blockers memantine and ketamine in rats. Pharmacology, Biochemistry and Behavior 109:67-76.

David M. Eckmann and Stephen C. Armstead (2013) Surfactant reduction of cerebral infarct size and behavioral deficit in a rat model of cerebrovascular arterial gas embolism. Journal of Applied Physiology 115:868-876.

Cole, C.J., Mercaldo, V., Restivo, L., Yiu, A.P., Sekeres, M.J., Han, J.H., Vetere, G., Pekar, T., Ross, P.J., Neve, R.L., et al. (2012). MEF2 negatively regulates learning-induced structural plasticity and memory formation. Nature Neuroscience 15:1255-1264.

Yang, M., Bozdagi, O., Scattoni, M.L., Wohr, M., Roullet, F.I., Katz, A.M., Abrams, D.N., Kalikhman, D., Simon, H., Woldeyohannes, L., et al. (2012). Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant mice.Journal of Neuroscience 32:6525-6541.

Martinez-Canabal, A., Akers, K.G., Josselyn, S.A., and Frankland, P.W. (2013). Age-dependent effects of hippocampal neurogenesis suppression on spatial learning. Hippocampus 23:66-74.

Hofmann, M., Kordas, K.S., Gravius, A., Bolcskei, K., Parsons, C.G., Dekundy, A., Danysz, W., Dezsi, L., Wittko-Schneider, I.M., Saghy, K., et al. (2012). Assessment of the effects of NS11394 and L-838417, alpha2/3 subunit-selective GABAA receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function. Behavioural Pharmacology 23:790-801.

Mansouri, A., Min, W., Cole, C.J., Josselyn, S.A., Henderson, J.T., van Eede, M., Henkelman, R.M., Ackerley, C., Grunebaum, E., and Roifman, C.M. (2012). Cerebellar abnormalities in purine nucleoside phosphorylase deficient mice. Neurobiology of Disease 47:201-209.

Pezze, M., and Bast, T. (2012). Dopaminergic modulation of hippocampus-dependent learning: blockade of hippocampal D1-class receptors during learning impairs 1-trial place memory at a 30-min retention delay. Neuropharmacology 63:710-718.

Kong, F.J., Ma, L.L., Hu, W.W., Wang, W.N., Lu, H.S., and Chen, S.P. (2012). Fetal exposure to high isoflurane concentration induces postnatal memory and learning deficits in rats.Biochemical Pharmacology 84:558-563.

Yang, M., Abrams, D.N., Zhang, J.Y., Weber, M.D., Katz, A.M., Clarke, A.M., Silverman, J.L., and Crawley, J.N. (2012). Low sociability in BTBR T+tf/J mice is independent of partner strain.Physiol Behav 107:649-662.

Bingham, D., Martin, S.J., Macrae, I.M., and Carswell, H.V. (2012). Watermaze performance after middle cerebral artery occlusion in the rat: the role of sensorimotor versus memory impairments. Journal of cerebral blood flow and metabolism. Journal of the International Society of Cerebral Blood Flow and Metabolism 32:989-999.

Mehrdad Faizia, Patrick L. Baderb, Christine Tuna, Angelo Encarnaciona, Alexander Kleschevnikovc, Pavel Belichenkoc, Nay Sawa, Matthew Priestleya, Richard W. Tsienb, William C. Mobleyc, Mehrdad Shamloo (2011) Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down Syndrome: Activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer. Neurobiology of Disease 43:397-413.

Baker, K.B., Wray, S.P., Ritter, R., Mason, S., Lanthorn, T.H., and Savelieva, K.V. (2010). Male and female Fmr1 knockout mice on C57 albino background exhibit spatial learning and memory impairments. Genes, Brain, and Behavior 9:562-574.

Luis Escribano, Ana-María Simón, Esther Gimeno, Mar Cuadrado-Tejedor, Rakel López de Maturana, Ana García-Osta, Ana Ricobaraza, Alberto Pérez-Mediavilla, Joaquín Del Río and Diana Frechilla (2010) Rosiglitazone Rescues Memory Impairment in Alzheimer’s Transgenic Mice: Mechanisms Involving a Reduced Amyloid and Tau Pathology.Neuropsychopharmacology 35:1593–1604.

Megan C. Holmes, Roderick N. Carter, June Noble, Shruti Chitnis, Amy Dutia, Janice M. Paterson, John J. Mullins, Jonathan R. Seckl and Joyce L. W. Yau (2010 )11β-Hydroxysteroid Dehydrogenase Type 1 Expression Is Increased in the Aged Mouse Hippocampus and Parietal Cortex and Causes Memory Impairments. Journal of Neuroscience 30:6916-6920.

Ana Ricobaraza, Mar Cuadrado-Tejedor, Alberto Pérez-Mediavilla, Diana Frechilla, Joaquin Del Río and Ana García-Osta (2009) Phenylbutyrate Ameliorates Cognitive Deficit and Reduces Tau Pathology in an Alzheimer’s Disease Mouse Model. Neuropsychopharmacology 34:1721–1732.

Katsuhiko Tabuchi, Guiquan Chen, Thomas C. Südhof and Jie Shen (2009) Conditional Forebrain Inactivation of Nicastrin Causes Progressive Memory Impairment and Age-Related Neurodegeneration. Journal of Neuroscience 29:7290-7301.

Bing-Xing Pan, Francois Vautier, Wataru Ito, Vadim Y. Bolshakov and Alexei Morozov (2008) Enhanced Cortico-Amygdala Efficacy and Suppressed Fear in Absence of Rap1. Journal of Neuroscience 28:2089-2098.

Yasuji Matsuoka, Yan Jouroukhin, Audrey J. Gray, Li Ma, Chiho Hirata-Fukae, Hui-Fang Li, Li Feng, Laurent Lecanu, Benjamin R. Walker, Emmanuel Planel, Ottavio Arancio, Illana Gozes, and Paul S. Aisen (2008) A Neuronal Microtubule-Interacting Agent, NAPVSIPQ, Reduces Tau Pathology and Enhances Cognitive Function in a Mouse Model of Alzheimer’s Disease. Journal of Pharmacology And Experimental Therapeutics 325:146-153.

Brandon J. Cornejoa, Michael H. Meschesa, Timothy A. Benke (2008) A single early-life seizure impairs short-term memory but does not alter spatial learning, recognition memory, or anxiety.Epilepsy & Behavior 13:585-592.

B. C. McKinney, J. S. Schneider, G. L. Schafer, J. L. Lowing, S. Mohan, M. X. Zhao, M. Y. Heng, R. L. Albin, A. F. Seasholtz, H. Akil, G. G. Murphy (2008) Decreased locomotor activity in mice expressing tTA under control of the CaMKIIα promoter. Genes, Brain and Behavior 7:203-213.

Feng Liu, Mark Day, Luis C Muñiz, Daniel Bitran, Robert Arias, Raquel Revilla-Sanchez, Steve Grauer, Guoming Zhang, Cody Kelley, Virginia Pulito, Amy Sung, Ronald F Mervis, Rachel Navarra, Warren D Hirst, Peter H Reinhart, Karen L Marquis, Stephen J Moss, Menelas N Pangalos & Nicholas J Brandon (2008) Activation of estrogen receptor- regulates hippocampal synaptic plasticity and improves memory. Nature Neuroscience 11:334 – 343.

Richard E. Brown and Aimée A. Wong (2007) The influence of visual ability on learning and memory performance in 13 strains of mice. Learning and Memory 14:134-144.

Nohjin Kee1, Cátia M Teixeira, Afra H Wang, & Paul W Frankland (2007) Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus. Nature Neuroscience 10:355 – 362.

Nohjin Kee1, Cátia M Teixeira, Afra H Wang, & Paul W Frankland (2007) Imaging activation of adult-generated granule cells in spatial memory. Nature Protocols 2:3033-3044

Cátia M. Teixeira, Stephen R. Pomedli, Hamid R. Maei, Nohjin Kee, and Paul W. Frankland (2006) Involvement of the Anterior Cingulate Cortex in the Expression of Remote Spatial Memory. Journal of Neuroscience 26:7555-7564.

Alvin V. Terry, Jr., Vinay Parikh, Debra A. Gearhart, Anilkumar Pillai, Elizabeth Hohnadel, Samantha Warner, Henry A. Nasrallah, and Sahebarao P. Mahadik (2006) Time-Dependent Effects of Haloperidol and Ziprasidone on Nerve Growth Factor, Cholinergic Neurons, and Spatial Learning in Rats. Journal of Pharmacology And Experimental Therapeutics 318:709-724.

Carlos A. Saura, Guiquan Chen, Seema Malkani, Se-Young Choi, Reisuke H. Takahashi, Dawei Zhang, Gunnar K. Gouras, Alfredo Kirkwood, Richard G. M. Morris and Jie Shen (2005) Conditional Inactivation of Presenilin 1 Prevents Amyloid Accumulation and Temporarily Rescues Contextual and Spatial Working Memory Impairments in Amyloid Precursor Protein Transgenic Mice (2005) Journal of Neuroscience 25:6755-6764.

Colin M. O’Carroll, Stephen J. Martin, Johan Sandin, Bruno Frenguelli, Richard G.M. Morris (2006) Dopaminergic modulation of the persistence of one-trial hippocampus-dependent memory. Learning & Memory 13:760–769.

Crabbe JC, Morris RG. (2004) Festina lente: late-night thoughts on high-throughput screening of mouse behavior.Nature Neuroscience 7:1175-9.

Daniel, A.C, Mesches, M.H., Alvarez, E., Bickford, P.C., and Browning, M.D. (2004) A Hippocampal NR2B Deficit Can Mimic Age-Related Changes in Long-Term Potentiation and Spatial Learning in the Fischer 344 Rat. Journal of Neuroscience, 22:3628-3637.

Livia de Hoz , Stephen J. Martin, Richard G. M. Morris (2004) Forgetting, Reminding, and Remembering: The Retrieval of Lost Spatial Memory. PLoS Biology 2:1233-1242.

Korzus, E., Rosenfeld, M.G. and Mayford, M (2004) CBP Histone Acetyltransferase Activity Is a Critical Component of Memory Consolidation. Neuron 42:961-972.

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LimeLight (Top)

Wagnon, J.L., Korn, M.J., Parent, R., Tarpey, T.A., Jones, J.M., Hammer, M.F., Murphy, G.G., Parent, J.M., and Meisler, M.H. (2015). Convulsive seizures and SUDEP in a mouse model of SCN8A epileptic encephalopathy. Human molecular genetics 24, 506-515.

Dias, B.G., Goodman, J.V., Ahluwalia, R., Easton, A.E., Andero, R., and Ressler, K.J. (2014). Amygdala-dependent fear memory consolidation via miR-34a and Notch signaling. Neuron 83, 906-918.

Ohmura, Y., Tanaka, K.F., Tsunematsu, T., Yamanaka, A., and Yoshioka, M. (2014). Optogenetic activation of serotonergic neurons enhances anxiety-like behaviour in mice. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum 17, 1777-1783.

Mastwal, S., Ye, Y., Ren, M., Jimenez, D.V., Martinowich, K., Gerfen, C.R., and Wang, K.H. (2014). Phasic dopamine neuron activity elicits unique mesofrontal plasticity in adolescence. The Journal of neuroscience : the official journal of the Society for Neuroscience 34, 9484-9496.

Dewan A, Pacifico R, Zhan R, Rinberg D, Bozza T. (2013) Non-redundant coding of aversive odours in the main olfactory pathway. Nature. 497:486-489.

Timothy P. O’Leary and Richard E. Brown (2013) Optimization of apparatus design and behavioral measures for the assessment of visuo-spatial learning and memory of mice on the Barnes maze. Learning and Memory 20: 85-96.

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Monje, F.J., Kim, E.J., Pollak, D.D., Cabatic, M., Li, L., Baston, A., and Lubec, G. (2012). Focal adhesion kinase regulates neuronal growth, synaptic plasticity and hippocampus-dependent spatial learning and memory. Neuro-Signals 20:1-14.

Nakamura, K., Itoh, K., Dai, H., Han, L., Wang, X., Kato, S., Sugimoto, T., and Fushiki, S. (2012). Prenatal and lactational exposure to low-doses of bisphenol A alters adult mice behavior. Brain & Development 34:57-63.

Harris, A.P., Holmes, M.C., de Kloet, E.R., Chapman, K.E., and Seckl, J.R. (2012). Mineralocorticoid and glucocorticoid receptor balance in control of HPA axis and behaviour.Psychoneuroendocrinology.

O’Leary, T.P., and Brown, R.E. (2013). Optimization of apparatus design and behavioral measures for the assessment of visuo-spatial learning and memory of mice on the Barnes maze.Learn Mem 20, 85-96.

Harris, A.P., Holmes, M.C., de Kloet, E.R., Chapman, K.E., and Seckl, J.R. (2012). Mineralocorticoid and glucocorticoid receptor balance in control of HPA axis and behaviour.Psychoneuroendocrinology (online).

Yamaguchi, T., Tsujimatsu, A., Kumamoto, H., Izumi, T., Ohmura, Y., Yoshida, T., and Yoshioka, M. (2012). Anxiolytic effects of yokukansan, a traditional Japanese medicine, via serotonin 5-HT1A receptors on anxiety-related behaviors in rats experienced aversive stress. Journal of Ethnopharmacology 143, 533-539.

Anne Marie Wissman, Andrew F. McCollum, Guang-Zhe Huang, Amisra A. Nikrodhanond and Catherine S. Woolley (2011) Sex differences and effects of cocaine on excitatory synapses in the nucleus accumbens. Neuropharmacology 61:217-227.

Francisco J. Monje, Maureen Cabatic1, Isabella Divisch, Eun-Jung Kim, Kurt R. Herkner3, Bernd R. Binder and Daniela D. Pollak1(2011) Constant Darkness Induces IL-6-Dependent Depression-Like Behavior through the NF-κB Signaling Pathway. Journal of Neuroscience31:9075-9083.

Vivek Kumar, Kyungin Kim, Chryshanthi Joseph, Lisa C. Thomas, Heekyung Hong, and Joseph S. Takahashi (2011) Second-generation high-throughput forward genetic screen in mice to isolate subtle behavioral mutants. PNAS 108:15557-15564.

Leanne M. Fraser, Richard E. Brown, Ahmed Hussin, Mara Fontana, Ashley Whittaker, Timothy P. O’Leary, Lauren Lederle, Andrew Holmes and André Ramos (2010) Measuring anxiety- and locomotion-related behaviours in mice: a new way of using old tests. Psychopharmacology211:99-112.

Tomoko Sogaa, Corresponding Author Contact Information, E-mail The Corresponding Author, Dutt Way Wonga, Iain J. Clarkeb, Ishwar S. Parhara (2010) Citalopram (antidepressant) administration causes sexual dysfunction in male mice through RF-amide related peptide in the dorsomedial hypothalamus. Neuropharmacology 59:77-85.

Karen Sooy, Scott P. Webster, June Noble, Margaret Binnie, Brian R. Walker, Jonathan R. Seckl and Joyce L. W. Yau (2010) Partial Deficiency or Short-Term Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Improves Cognitive Function in Aging Mice. Journal of Neuroscience30:13867-13872.

S. K. Segall1, A. G. Nackley, L. Diatchenko, W. R. Lariviere, X. Lu, J. S. Marron, L. Grabowski-Boase, J. R. Walker, G. Slade, J. Gauthier, J. S. Bailey, B. M. Steffy, T. M. Maynard, L. M. Tarantino and T. Wiltshire (2010) Comt1 genotype and expression predicts anxiety and nociceptive sensitivity in inbred strains of mice. Genes, Brain and Behavior 9:933–946.

Yoko Nawata, Takato Hiranita and Tsuneyuki Yamamoto (2010) A Cannabinoid CB1 Receptor Antagonist Ameliorates Impairment of Recognition Memory on Withdrawal from MDMA (Ecstasy). Neuropsychopharmacology 35, 515–520.

Yu Ohmura1,2, Takeshi Izumi1, Taku Yamaguchi1, Iku Tsutsui-Kimura1, Takayuki Yoshida1 and Mitsuhiro Yoshioka1 (2010) The Serotonergic Projection from the Median Raphe Nucleus to the Ventral Hippocampus is Involved in the Retrieval of Fear Memory Through the Corticotropin-Releasing Factor Type 2 Receptor. Neuropsychopharmacology 35, 1271–1278.

Liat Levita, Jayant Kulkarni, Joseph Monaco, Clifford Kentros, Matthew Stead, Larry F. Abbott, Eric R. Kandel (2009) Attention Enhances the Retrieval and Stability of Visuospatial and Olfactory Representations in the Dorsal Hippocampus. PLoS Biology 7:e1000140.

Timothy P. O’Leary and Richard E. Brown (2009) Visuo-spatial learning and memory deficits on the Barnes maze in the 16-month-old APPswe/PS1dE9 mouse model of Alzheimer’s disease.Behavioral Brain Research 201:120-127.

B. C. McKinney, C. Y. Chow, M. H. Meisler, G. G. Murphy (2008) Exaggerated emotional behavior in mice heterozygous null for the sodium channel Scn8a (Nav1.6). Genes, Brain and Behavior 7:629-638.

Yu Ohmura, Taku Yamaguchia, Takeshi Izumia, Machiko Matsumotoa and Mitsuhiro Yoshioka (2008) Corticotropin releasing factor in the median raphe nucleus is involved in the retrieval of fear memory in rats. European Journal of Pharmacology 584:357-360.

Hyung Jin Ahn, Caterina M. Hernandez, Jonathan M. Levenson, Farah D. Lubin, Hsiou-Chi Liou, and J. David Sweatt (2008) c-Rel, an NF-κB family transcription factor, is required for hippocampal long-term synaptic plasticity and memory formation. Learning and Memory15:539-549.

Daniel J. Abramsa, Lijun Zhenga, Kevin S. Chooa, Jun J. Yangb, Wei Weid, Thomas J. Anchordoquyb, Nasser H. Zawiad and Karen E. Stevens (2008) An initial animal proof-of-concept study for central administration of clozapine to schizophrenia patients. Schizophrenia Research In Press.

B. C. McKinney, J. S. Schneider, G. L. Schafer, J. L. Lowing, S. Mohan, M. X. Zhao, M. Y. Heng, R. L. Albin, A. F. Seasholtz, H. Akil, G. G. Murphy (2007) Decreased locomotor activity in mice expressing tTA under control of the CaMKIIα promoter. Genes, Brains and Behavior 7:203-213.

Maggie Lai, Karen Horsburgh, Sung-Eun Bae, Roderick N. Carter, Dirk J. Stenvers, Jill H. Fowler, Joyce L. Yau, Celso E. Gomez-Sanchez, Megan C. Holmes, Christopher J. Kenyon, Jonathan R. Seckl, Malcolm R. Macleod (2007) Forebrain mineralocorticoid receptor overexpression enhances memory, reduces anxiety and attenuates neuronal loss in cerebral ischaemia European Journal of Neuroscience 25:1832–1842.

Heidi G. Sutherland, Kathryn Newton, David G. Brownstein, Megan C. Holmes, Clémence Kress, Colin A. Semple, and Wendy A. Bickmore (2006) Disruption of Ledgf/Psip1 Results in Perinatal Mortality and Homeotic Skeletal Transformations. Molecular and Cellular Biology, 26:7201-7210.

Megan C. Holmes, Christian T. Abrahamsen, Karen L. French, Janice M. Paterson, John J. Mullins, and Jonathan R. Seckl (2006) The Mother or the Fetus? 11-Hydroxysteroid Dehydrogenase Type 2 Null Mice Provide Evidence for Direct Fetal Programming of Behavior by Endogenous Glucocorticoids. Journal of Neuroscience, 26:3840-3844.

Rong Chen, Michael R. Tilley, Hua Wei, Fuwen Zhou, Fu-Ming Zhou, San Ching, Ning Quan, Robert L. Stephens, Erik R. Hill, Timothy Nottoli, Dawn D. Han, and Howard H. Gu (2006) Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter.PNAS103:9333-9338.

Michael T. Rogan, Kam Sam Leon, David L. Perez, and Eric R. Kandel (2005) Distinct Neural Signatures for Safety and Danger in the Amygdala and Striatum of the Mouse. Neuron 46:1–12.

ClockLab (Top)

Chak Foon Tso, Tatiana Simon, Alison C. Greenlaw, Tanvi Puri, Michihiro Mieda, Erik D. Herzog (2017). Astrocytes Regulate Daily Rhythms in the Suprachiasmatic Nucleus and Behavior. Current Biology (online prepublication).

Bedont, J.L., LeGates, T.A., Slat, E.A., Byerly, M.S., Wang, H., Hu, J., Rupp, A.C., Qian, J., Wong, G.W., Herzog, E.D., et al. (2014). Lhx1 controls terminal differentiation and circadian function of the suprachiasmatic nucleus. Cell reports 7, 609-622.

Azzi, A., Dallmann, R., Casserly, A., Rehrauer, H., Patrignani, A., Maier, B., Kramer, A., and Brown, S.A. (2014). Circadian behavior is light-reprogrammed by plastic DNA methylation. Nature Neuroscience 17, 377-382.

Hatori, M., Gill, S., Mure, L.S., Goulding, M., O’Leary, D.D., and Panda, S. (2014). Lhx1 maintains synchrony among circadian oscillator neurons of the SCN. eLife 3, e03357.

Liu, S., Lamaze, A., Liu, Q., Tabuchi, M., Yang, Y., Fowler, M., Bharadwaj, R., Zhang, J., Bedont, J., Blackshaw, S., et al. (2014). WIDE AWAKE mediates the circadian timing of sleep onset. Neuron 82, 151-166.

Cavanaugh, D.J., Geratowski, J.D., Wooltorton, J.R., Spaethling, J.M., Hector, C.E., Zheng, X., Johnson, E.C., Eberwine, J.H., and Sehgal, A. (2014). Identification of a circadian output circuit for rest:activity rhythms in Drosophila. Cell 157, 689-701.

Balmert, N.J., Rund, S.S., Ghazi, J.P., Zhou, P., and Duffield, G.E. (2014). Time-of-day specific changes in metabolic detoxification and insecticide resistance in the malaria mosquito Anopheles gambiae. Journal of Insect Physiology 64, 30-39.

Seung-Hee Yoo, Jennifer A. Mohawk, Sandra M. Siepka, Yongli Shan, Seong Kwon Huh, Hee-Kyung Hong, Izabela Kornblum, Vivek Kumar, Nobuya Koike, Ming Xu, Justin Nussbaum, Xinran Liu, Zheng Chen, Zhijian J. Chen, Carla B. Green, Joseph S. Takahashi (2013) Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm. Cell 28:1091–1105.

Michael A. Crickmore, Leslie B. Vosshall (2013) Opposing Dopaminergic and GABAergic Neurons Control the Duration and Persistence of Copulation in Drosophila, Cell 155:881-893.

Tracy A. Bedrosian, Celynn A. Vaughn, Anabel Galan, Ghassan Daye, Zachary M. Weil, and Randy J. Nelson (2013) Nocturnal Light Exposure Impairs Affective Responses in a Wavelength-Dependent Manner. Journal of Neuroscience33:13081-13087.

Sungwon An, Rich Harang, Kirsten Meeker, Daniel Granados-Fuentes, Connie A. Tsai, Cristina Mazuski, Jihee Kim, Francis J. Doyle III, Linda R. Petzold, and Erik D. Herzog (2013) A neuropeptide speeds circadian entrainment by reducing intercellular synchrony. PNAS110:E4355-E4361

Zhang L, Hastings MH, Green EW, Tauber E, Sladek M, Webster SG, Kyriacou CP, Wilcockson (2013) Dissociation of circadian and circatidal timekeeping in the marine crustacean Eurydice pulchra. DC. Current Biology 23:1863-73.

LeGates, T.A., Altimus, C.M., Wang, H., Lee, H.K., Yang, S., Zhao, H., Kirkwood, A., Weber, E.T., and Hattar, S. (2012). Aberrant light directly impairs mood and learning through melanopsin-expressing neurons. Nature 491:594-598.

Fonken, L.K., Kitsmiller, E., Smale, L., and Nelson, R.J. (2012). Dim nighttime light impairs cognition and provokes depressive-like responses in a diurnal rodent. Journal of Biological Rhythms 27:319-327.

Eastwood, E., Allen, C.N., and Raber, J. (2012). Effects of neonatal methamphetamine and thioperamide exposure on spatial memory retention and circadian activity later in life.Behavioural Brain Research 230:229-236.

Karatsoreos, I.N., Bhagat, S., Bloss, E.B., Morrison, J.H., and McEwen, B.S. (2011). Disruption of circadian clocks has ramifications for metabolism, brain, and behavior. Proc Natl Acad Sci U S A 108, 1657-1662.

Luciano DiTacchio, Hiep D. Le, Christopher Vollmers, Megumi Hatori, Michael Witcher, Julie Secombe, Satchidananda Panda (2011) Histone Lysine Demethylase JARID1a Activates CLOCK-BMAL1 and Influences the Circadian Clock. Science 333:1881-1885.

S.-K. Chen, T. C. Badea & S. Hattar (2011) Photoentrainment and pupillary light reflex are mediated by distinct populations of ipRGCs. Nature 476:92–95.

Gareth T. Banks and Patrick M. Nolan (2011) Assessment of Circadian and Light-Entrainable Parameters in Mice Using Wheel-Running Activity. Current Protocols in Mouse Biology 369–381.

Takashi Kudo, Dawn H. Loh, Dika Kuljis, Cara Constance, and Christopher S. Colwell (2011) Fast Delayed Rectifier Potassium Current: Critical for Input and Output of the Circadian System.Journal of Neuroscience 31:2746-2755.

Tadahiro Goda, Karolina Mirowska1, Jake Currie, Min-Ho Kim, Neethi Varadaraja Rao, Gloribel Bonilla, Herman Wijnen (2011) Adult Circadian Behavior in Drosophila Requires Developmental Expression of cycle, But Not period. PLoS Genetics 7:e1002167.

Tara A. LeGates, Cara M. Altimus (2011) Measuring Circadian and Acute Light Responses in Mice using Wheel Running Activity. Journal of Visualized Experiments 48:e2463.

Catherine R. Dufour, Marie-Pier Levasseur, Nguyen Hoai Huong Pham, Lillian J. Eichner, Brian J. Wilson, Alexis Charest-Marcotte, David Duguay, Jean-François Poirier-Héon, Nicolas Cermakian, Vincent Giguère (2011) Genomic Convergence among ERRα, PROX1, and BMAL1 in the Control of Metabolic Clock Outputs. PLoS Genetics 7:e1002143.

Masao Doi, Atsushi Ishida, Akiko Miyake, Miho Sato, Rie Komatsu, Fumiyoshi Yamazaki, Ikuo Kimura, Soken Tsuchiya, Hiroshi Kori, Kazuyuki Seo, Yoshiaki Yamaguchi, Masahiro Matsuo, Jean-Michel Fustin, Rina Tanaka, Yasuko Santo, Hiroyuki Yamada, Yukari Takahashi, Michihiro Araki, Kazuki Nakao, Shinichi Aizawa, Masaki Kobayashi, Karl Obrietan, Gozoh Tsujimoto & Hitoshi Okamura (2011) Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus. Nature Communications 2:#327.

Matthew P. Butler, Kevin W. Turner, Jin Ho Park, Elanor E. Schoomer, Irving Zucker and Michael R. Gorman (2010) Seasonal regulation of reproduction: altered role of melatonin under naturalistic conditions in hamsters (2010) Proc. R. Soc. B 277:2867-2874

Florence J. Blanchard, Ben Collins, Shawn A. Cyran, Daniel H. Hancock, Michael V. Taylor, and Justin Blau1 (2010) The Transcription Factor Mef2 Is Required for Normal Circadian Behavior in Drosophila. Journal of Neuroscience 30:5855-5865.

Akiko Satoh, Cynthia S. Brace, Gal Ben-Josef, Tim West, David F. Wozniak, David M. Holtzman, Erik D. Herzog (2010) SIRT1 Promotes the Central Adaptive Response to Diet Restriction through Activation of the Dorsomedial and Lateral Nuclei of the Hypothalamus.Journal of Neuroscience 30:10220-10232

Coy D Heldermon, Kevin K Ohlemiller, Erik D Herzog, Carole Vogler, Elizabeth Qin, David F Wozniak, Yun Tan, John L Orrock and Mark S Sands (2010) Therapeutic Efficacy of Bone Marrow Transplant, Intracranial AAV-mediated Gene Therapy, or Both in the Mouse Model of MPS IIIB. Molecular Therapy 18:873–880.

Julie S. Pendergast, Rio C. Friday, and Shin Yamazaki (2009) Endogenous Rhythms in Period1 Mutant Suprachiasmatic Nuclei In Vitro Do Not Represent Circadian Behavior. Journal of Neuroscience 29:14681-14686.

Alain Gobert, Mauricette Brocco, Anne Dekeyne, Benjamin Di Cara, Gaëlle Bouchez, Françoise Lejeune, Robert L Gannon and Mark J Millan (2009) Neurokinin1 Antagonists Potentiate Antidepressant Properties of Serotonin Reuptake Inhibitors, Yet Blunt Their Anxiogenic Actions: A Neurochemical, Electrophysiological, and Behavioral Characterization.Neuropsychopharmacology 34:1039–1056.

Jae Hoon Bahn, Gyunghee Lee and Jae H. Park (2009) Comparative Analysis of Pdf-Mediated Circadian Behaviors Between Drosophila melanogaster and D. virilis. Genetics 181:965-975.

Ali D. Güler, Jennifer L. Ecker, Gurprit S. Lall, Shafiqul Haq, Cara M. Altimus, Hsi-Wen Liao, Alun R. Barnard, Hugh Cahill, Tudor C. Badea, Haiqing Zhao, Mark W. Hankins, David M. Berson, Robert J. Lucas, King-Wai Yau & Samer Hattar (2008) Melanopsin cells are the principal conduits for rod–cone input to non-image-forming vision. Nature 453:102-105.

Elaine M. Smith, Jui-Ming Lin, Rose-Anne Meissner, Ravi Allada (2008) Dominant-Negative CK2α Induces Potent Effects on Circadian Rhythmicity. PLoS Genetics 4:[epub].

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Maureen K. Bunger, Lisa D. Wilsbacher, Susan M. Moran, Cynthia Clendenin, Laurel A. Radcliffe, John B. Hogenesch, M.Celeste Simon, Joseph S. Takahashi and Christopher A. Bradfield (2008) Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals Cell 103:1009-1017.

Norman F. Ruby, Calvin E. Hwang, Colin Wessells, Fabian Fernandez, Pei Zhang, Robert Sapolsky, and H. Craig Heller (2008) Hippocampal-dependent learning requires a functional circadian system. PNAS 105:15593-15598.

Sofia I. H. Godinho, Elizabeth S. Maywood, Linda Shaw, Valter Tucci, Alun R. Barnard, Luca Busino, Michele Pagano, Rachel Kendall, Mohamed M. Quwailid, M. Rosario Romero, John O’Neill, Johanna E. Chesham, Debra Brooker, Zuzanna Lalanne, Michael H. Hastings, Patrick M. Nolan. (2007) The After Hours Mutant Reveals a Role for FBXL3 in Determining Mammalian Circadian Period. Science 316: 900-904.

Quan Yuan, William J. Joiner and Amita Sehgal (2006) A Sleep-Promoting Role for the Drosophila Serotonin Receptor. Current Biology 16:1051-1062.

Andrea L Meredith, Steven W Wiler, Brooke H Miller, Joseph S Takahashi, Anthony A Fodor, Norman F Ruby & Richard W Aldrich (2006) BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output. Nature Neuroscience 9:1041-1049.

Maureen K. Bunger, Lisa D. Wilsbacher, Susan M. Moran, Cynthia Clendenin, Laurel A. Radcliffe, John B. Hogenesch, M. Celeste Simon, Joseph S. Takahashi and Christopher A. Bradfield (2006) Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals. Cell, 103:1009-1017.

J. DeBruyne, E. Noton, C. Lambert, E. Maywood, D. Weaver, S. Reppert (2006) A Clock Shock: Mouse CLOCK Is Not Required for Circadian Oscillator Function. Neuron, 50:465-477.

Michael N. Nitabach, Ying Wu, Vasu Sheeba, William C. Lemon, John Strumbos, Paul K. Zelensky, Benjamin H. White and Todd C. Holmes (2006) Electrical Hyperexcitation of Lateral Ventral Pacemaker Neurons Desynchronizes Downstream Circadian Oscillators in the Fly Circadian Circuit and Induces Multiple Behavioral Periods. Journal of Neuroscience 26:479-489.

Susan E. Doyle, Ana Maria Castrucci, Maureen McCall, Ignacio Provencio, and Michael Menaker (2006) Nonvisual light responses in the Rpe65 knockout mouse: Rod loss restores sensitivity to the melanopsin system. PNAS 103:10432-10437.

Xiaodong Li, Jenifer Gilbert and Fred C. Davis (2005) Disruption of masking by hypothalamic lesions in Syrian hamsters Journal of Comparative Physiology 191:23-30.

A. Jennifer Morton, Nigel I. Wood, Michael H. Hastings, Carrie Hurelbrink, Roger A. Barker, and Elizabeth S. Maywood (2005) Disintegration of the Sleep-Wake Cycle and Circadian Timing in Huntington’s Disease. Journal of Neuroscience 25:157-163.

Sara J Aton, Christopher S Colwell, Anthony J Harmar, James Waschek& Erik D Herzog (2005) Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons. Nature Neuroscience 8:476 – 483.

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Granados-Fuentes, D., L. M. Prolo, U. Abraham and E. D. Herzog (2004). “The suprachiasmatic nucleus entrains, but does not sustain, circadian rhythmicity in the olfactory bulb.” Journal of Neuroscience 24(3): 615-9.

Granados-Fuentes, D., M. T. Saxena, L. M. Prolo, S. J. Aton and E. D. Herzog (2004). “Olfactory bulb neurons express functional, entrainable circadian rhythms.” European Journal of Neuroscience 19(4): 898-906.

Han SL, Nelms, JL, Nguyen, M, Silver, R & Lehman, MN (2003) The eye is necessary for a circadian rhythm in the suprachiasmatic nucleus. Nature Neuroscience 6:111-112.

Lin, J. M., V. L. Kilman, K. Keegan, B. Paddock, M. Emery-Le, M. Rosbash and R. Allada (2002). “A role for casein kinase 2alpha in the Drosophila circadian clock.” Nature 420(6917): 816-20.

Ruby, N. F., T. J. Brennan, X. Xie, V. Cao, P. Franken, H. C. Heller and B. F. O’Hara (2002). “Role of melanopsin in circadian responses to light.” Science 298(5601): 2211-3.

Castrucci, AM, Rollag,, MD, DeGrip, WJ, Hogenesch, JD, Provencio, I & Kay, SA (2002) Melanopsin (Opn4) Requirement for Normal Light-Induced Circadian Phase Shifting. Science298:2213-2215.

Daniel Gau, Thomas Lemberger, Charlotte von Gall, Oliver Kretz, Nguyet Le Minh, Peter Gass, Wolfgang Schmid, Ueli Schibler, Horst W. Korf, and Günther Schütz.(2002). Phosphorylation of CREB Ser142 Regulates Light-Induced Phase Shifts of the Circadian Clock. Neuron 34: 245-253.

Harmar AJ, Marston HM, Shen S, Spratt C, West KM, Sheward WJ, Morrison CF, Dorin JR, Piggins HD, Reubi JC, Kelly JS, Maywood ES, Hastings MH.(2002). The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei. Cell 109:497-508.

Williams, J. A., H. S. Su, A. Bernards, J. Field and A. Sehgal (2001). “A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK.” Science 293(5538): 2251-6.Panda, S, Sato. TK,Shen S, Spratt C, Sheward WJ, Kallo I, West K, Morrison CF, Coen CW, Marston HM, Harmar AJ.(2000). Overexpression of the human VPAC2 receptor in the suprachiasmatic nucleus alters the circadian phenotype of mice. PNAS 97:11575-80.

Sharon S. Low-Zeddies and Joseph S. Takahashi (2001). Chimera Analysis of the Clock Mutation in Mice Shows that Complex Cellular Integration Determines Circadian Behavior. Cell 105: 25-42.

Maureen K. Bunger, Lisa D. Wilsbacher, Susan M. Moran, Cynthia Clendenin, Laurel A. Radcliffe, John B. Hogenesch, M. Celeste Simon, Joseph S. Takahashi, and Christopher A. Bradfield (2000) Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals. Cell 103: 1009.


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Papp, S.J., Huber, A.L., Jordan, S.D., Kriebs, A., Nguyen, M., Moresco, J.J., Yates, J.R., and Lamia, K.A. (2015). DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. eLife 4.

Pilorz, V., Cunningham, P.S., Jackson, A., West, A.C., Wager, T.T., Loudon, A.S., and Bechtold, D.A. (2014). A novel mechanism controlling resetting speed of the circadian clock to environmental stimuli. Current biology 24, 766-773.

Kim, J.Y., Kwak, P.B., and Weitz, C.J. (2014). Specificity in circadian clock feedback from targeted reconstitution of the NuRD corepressor. Molecular Cell 56, 738-748.

Du, N.H., Arpat, A.B., De Matos, M., and Gatfield, D. (2014). MicroRNAs shape circadian hepatic gene expression on a transcriptome-wide scale. eLife 3, e02510.

Chaves, I., van der Horst, G.T., Schellevis, R., Nijman, R.M., Koerkamp, M.G., Holstege, F.C., Smidt, M.P., and Hoekman, M.F. (2014). Insulin-FOXO3 signaling modulates circadian rhythms via regulation of clock transcription. Current biology 24, 1248-1255.

Nangle, S.N., Rosensweig, C., Koike, N., Tei, H., Takahashi, J.S., Green, C.B., and Zheng, N. (2014). Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex. eLife 3, e03674.

Lin, S.T., Zhang, L., Lin, X., Zhang, L.C., Garcia, V.E., Tsai, C.W., Ptacek, L., and Fu, Y.H. (2014). Nuclear envelope protein MAN1 regulates clock through BMAL1. eLife 3, e02981.

Buhr, E.D., and Van Gelder, R.N. (2014). Local photic entrainment of the retinal circadian oscillator in the absence of rods, cones, and melanopsin. Proceedings of the National Academy of Sciences 111, 8625-8630.

Mian Zhou, Jinhu Guo, Joonseok Cha, Michael Chae, She Chen, Jose M. Barral, Matthew S. Sachs & Yi Liu (2013). Non-optimal codon usage affects expression, structure and function of clock protein FRQ. Nature 495:111-5.

Xu Y, Ma P, Shah P, Rokas A, Liu Y, Johnson CH. (2013) Non-optimal codon usage is a mechanism to achieve circadian clock conditionality. Nature. 495:116-20.

A. Jagannath, Rachel Butler, S. I.H. Godinho, Y. Couch, L. A. Brown, S. R. Vasudevan, K. C. Flanagan, D. Anthony, G. C. Churchill, M. J.A. Wood, G. Steiner, G. Ebeling, G. Hossbach, J. G. Wettstein, G. E. Duffield, S. Gatti, M. W. Hankins, R. G. Foster, and S. N. Peirson (2013) The CRTC1-SIK1 Pathway Regulates Entrainment of the Circadian Clock Cell. 154:1100–1111.

Cao R, Robinson B, Xu H, Gkogkas C, Khoutorsky A, Alain T, Yanagiya A, Nevarko T, Liu AC, Amir S, Sonenberg N. (2103) Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling. Neuron 79:712-24.

Daisuke Ono, Sato Honma & Ken-ichi Honma (2013) Cryptochromes are critical for the development of coherent circadian rhythms in the mouse suprachiasmatic nucleus Nature Communication 4:1666.

Seung-Hee Yoo, Jennifer A. Mohawk, Sandra M. Siepka, Yongli Shan, Seong Kwon Huh, Hee-Kyung Hong, Izabela Kornblum, Vivek Kumar, Nobuya Koike, Ming Xu, Justin Nussbaum, Xinran Liu, Zheng Chen, Zhijian J. Chen, Carla B. Green, Joseph S. Takahashi (2013) Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm. Cell 28:1091–1105

Laura Lande-Diner, Cyril Boyault, Jin Young Kim, and Charles J. Weitz (2013) A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery PNAS 110:16021-16026.

Zhipeng Zhoua, Xiao Liua, Qiwen Hua, Ning Zhanga, Guangyan Suna, Joonseok Chac, Ying Wanga, Yi Liuc, and Qun Hea (2013) Suppression of WC-independent frequency transcription by RCO-1 is essential for Neurospora circadian clock. PNAS 10:E4867-E4874

Hinard, V., Mikhail, C., Pradervand, S., Curie, T., Houtkooper, R.H., Auwerx, J., Franken, P., and Tafti, M. (2012). Key electrophysiological, molecular, and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures. Journal of Neuroscience 32:12506-12517.

Jackson, C.R., Ruan, G.X., Aseem, F., Abey, J., Gamble, K., Stanwood, G., Palmiter, R.D., Iuvone, P.M., and McMahon, D.G. (2012). Retinal dopamine mediates multiple dimensions of light-adapted vision. Journal of Neuroscience32:9359-9368.

Tong, X., Buelow, K., Guha, A., Rausch, R., and Yin, L. (2012). USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signals. Journal of Biological Chemistry 287:25280-25291.

Sellix, M.T., Evans, J.A., Leise, T.L., Castanon-Cervantes, O., Hill, D.D., DeLisser, P., Block, G.D., Menaker, M., and Davidson, A.J. (2012). Aging differentially affects the re-entrainment response of central and peripheral circadian oscillators. Journal of Neuroscience 32:16193-16202.

Wang, Z., Wu, Y., Li, L., and Su, X.D. (2012). Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA.Cell researchepub 12/2012

Khan, S.K., Xu, H., Ukai-Tadenuma, M., Burton, B., Wang, Y., Ueda, H.R., and Liu, A.C. (2012). Identification of a novel cryptochrome differentiating domain required for feedback repression in circadian clock function. Journal of Biological Chemistry 287:25917-25926.

Takahiro J. Nakamura, Wataru Nakamura, Shin Yamazaki, Takashi Kudo1, Tamara Cutler, Christopher S. Colwell1, and Gene D. Block1(2011) Age-Related Decline in Circadian Output.Journal of Neuroscience, 31:10201-10205.

Maki Ukai-Tadenuma, Rikuhiro G. Yamada, Haiyan Xu, Jürgen A. Ripperger, Andrew C. Liu, Hiroki R. Ueda (2011) Delay in Feedback Repression by Cryptochrome 1 Is Required for Circadian Clock Function. Cell 144:268-281.

Savelyev, S. A., Larsson, K. C., Johansson, A. ., Lundkvist, G. B. S. (2011) Slice Preparation, Organotypic Tissue Culturing and Luciferase Recording of Clock Gene Activity in the Suprachiasmatic Nucleus. Journal of Visualized Experiments 48:e2439.

Nicholas C. Foley, Tina Y. Tong, Duncan Foley, Joseph LeSauter, David K. Welsh, Rae Silver (2011) Characterization of orderly spatiotemporal patterns of clock gene activation in mammalian suprachiasmatic nucleus. European Journal of Neuroscience 33:1851–1865.

Ethan D. Buhr, Seung-Hee Yoo and Joseph S. Takahashi (2010) Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators. Science 330:379-385.

Biliana Marcheva, Kathryn Moynihan Ramsey, Ethan D. Buhr, Yumiko Kobayashi, Hong Su, Caroline H. Ko, Ganka Ivanova, Chiaki Omura, Shelley Mo, Martha H. Vitaterna, James P. Lopez, Louis H. Philipson, Christopher A. Bradfield, Seth D. Crosby, Lellean JeBailey, Xiaozhong Wang, Joseph S. Takahashi and Joseph Bass (2010) Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature 466: 627–631.

Mijung Yeom, Julie S. Pendergast, Yoshihiro Ohmiya, and Shin Yamazaki (2010) Circadian-independent cell mitosis in immortalized fibroblasts. PNAS 107:9665-9670.

Isabelle Schmutz, Jürgen A. Ripperger, Stéphanie Baeriswyl-Aebischer and Urs Albrecht (2010) The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors. Genes & Development 24:345-357.

Markus Stratmann, Frédéric Stadler, Filippo Tamanini, Gijsbertus T.J. van der Horst and Jürgen A. Ripperger (2010) Flexible phase adjustment of circadian albumin D site-binding protein (Dbp) gene expression by CRYPTOCHROME1. Genes & Development 24:1317-1328.

Jorge Mendoza, Paul Pévet, Marie-Paule Felder-Schmittbuhl, Yannick Bailly and Etienne Challet. (2010) The Cerebellum Harbors a Circadian Oscillator Involved in Food Anticipation.Journal of Neuroscience, 3018:94-1904.

Eric E. Zhang, Andrew C. Liu, Tsuyoshi Hirota, Loren J. Miraglia, Genevieve Welch, Pagkapol Y. Pongsawakul, Xianzhong Liu, Ann Atwood, Jon W. Huss III, Jeff Janes, Andrew I. Su, and John B. Hogenesch (2009) A Genome-wide RNAi Screen for Modifiers of the Circadian Clock in Human Cells. Cell 139:199-210.

Laurent Meijer, Leandros Skaltsounis, Emmanuel Mikros, Prokopios Magiatis, Carl Johnson (2009) 3′,6-Substituted Indirubins and Their Biologicial Applications. US Patent Application20110136808.

Julie E. Baggs, Tom S. Price, Luciano DiTacchio, Satchidananda Panda, Garret A. FitzGerald, John B. Hogenesch (2009) Network Features of the Mammalian Circadian Clock. PLoS Biology7:e1000052.

Naohiro Kon, Tsuyoshi Hirota, Takeshi Kawamoto, Yukio Kato, Tadashi Tsubota and Yoshitaka Fukada (2008) Activation of tGF-β/activin signalling resets the circadian clock through rapid induction of Dec1 transcripts. Nature Cell Biology 10:1463-1469.

Andrew C. Liu, Hien G. Tran,, Eric E. Zhang, Aaron A. Priest, David K. Welsh and Steve A. Kay (2008) Redundant Function of REV-ERBα and β and Non-Essential Role for Bmal1 Cycling in Transcriptional Regulation of Intracellular Circadian Rhythms. PLoS Genetics 4:e1000023.

Steven A. Brown, Dieter Kunz, Amelie Dumas, Pål O. Westermark, Katja Vanselow, Amely Tilmann-Wahnschaffe, Hanspeter Herzel, and Achim Kramer (2008) Molecular insights into human daily behavior. PNAS 105:1602-1607

Wen-Ning Zhao, Nikolay Malinin, Fu-Chia Yang,, David Staknis, Nicholas Gekakis, Bert Maier, Silke Reischl, Achim Kramer & Charles J. Weitz (2007) CIPC is a mammalian circadian clock protein without invertebrate homologues. Nature Cell Biology 9:268-275.

Natsuko Inagaki, Sato Honma, Daisuke Ono, Yusuke Tanahashi, and Ken-ichi Honma (2007) Separate oscillating cell groups in mouse suprachiasmatic nucleus couple photoperiodically to the onset and end of daily activity. PNAS 104:7664-7669.

Mariko Izumo, Takashi R. Sato, Martin Straume, Carl Hirschie Johnson (2006) Quantitative Analyses of Circadian Gene Expression in Mammalian Cell Cultures. PLoS Computation Biology, 2:1248-1261.

Guo-Xiang Ruan, Dao-Qi Zhang, Tongrong Zhou, Shin Yamazaki, and Douglas G. McMahon (2006) Circadian organization of the mammalian retina. PNAS 103:9703-9708.

Katja Vanselow, Jens T. Vanselow, Pål O. Westermark, Silke Reischl, Bert Maier, Thomas Korte, Andreas Herrmann, Hanspeter Herzel2, Andreas Schlosser and Achim Kramer (2006) Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS). Genes and Development, 20:2660-2672.

Alec J. Davidson, Martin Straume, Gene D. Block, Michael Menaker (2006) Daily timed meals dissociate circadian rhythms in hepatoma and healthy host liver. International Journal of Cancer 118:1623-1627.

Martha Hotz Vitaterna, Caroline H. Ko, Anne-Marie Chang, Ethan D. Buhr, Ethan M. Fruechte, Andrew Schook, Marina P. Antoch, Fred W. Turek, and Joseph S. Takahashi (2006) The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase–response curve amplitude. PNAS 103:9327-9332.

Fukuhara C, Yamazaki S, Liang J. (2005) Pineal circadian clocks gate arylalkylamine N-acetyltransferase gene expression in the mouse pineal gland. Journal of Neurochemistry93:156-62

Chiaki Fukuhara, Shin Yamazaki and Jian Liang (2005) Pineal circadian clocks gate arylalkylamine N-acetyltransferase gene expression in the mouse pineal gland. Journal of Neurochemistry 93:1471-4159.

Yoo SH, Ko CH, Lowrey PL, Buhr ED, Song EJ, Chang S, Yoo OJ, Yamazaki S, Lee C, Takahashi JS. (2005) A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo.PNAS 102:2608-13.

David K. Welsh, Seung-Hee Yoo, Andrew C. Liu, Joseph S. Takahashi, and Steve A. Kay. (2004) Bioluminescence Imaging of Individual Fibroblasts Reveals Persistent, Independently Phased Circadian Rhythms of Clock Gene Expression. Current Biology 14:2289-95.

Mariko Izumo, Carl Hirschie Johnson and Shin Yamazaki (2003). Circadian gene expression in mammalian fibroblasts revealed by real-time luminescence reporting: Temperature compensation and damping. PNAS 100:16089-16094.

 

MultiCycle (Top)

Hirota, T., and Kay, S.A. (2015). Identification of small-molecule modulators of the circadian clock. Methods in enzymology 551, 267-282.

Ramanathan, C., Xu, H., Khan, S.K., Shen, Y., Gitis, P.J., Welsh, D.K., Hogenesch, J.B., and Liu, A.C. (2014). Cell type-specific functions of period genes revealed by novel adipocyte and hepatocyte circadian clock models. PLoS Genetics 10, e1004244.

Hoffmann, J., Symul, L., Shostak, A., Fischer, T., Naef, F., and Brunner, M. (2014). Non-circadian expression masking clock-driven weak transcription rhythms in U2OS cells. PloS One 9, e102238.

Chen, Z., Yoo, S.H., Park, Y.S., Kim, K.H., Wei, S., Buhr, E., Ye, Z.Y., Pan, H.L., and Takahashi, J.S. (2012). Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening. PNAS 109, 101-106.

Tataroglu, O., Lauinger, L., Sancar, G., Jakob, K., Brunner, M., and Diernfellner, A.C. (2012). Glycogen synthase kinase is a regulator of the circadian clock of Neurospora crassa. The Journal of Biological Chemistry 287, 36936-36943.

Sancar, G., Sancar, C., Brugger, B., Ha, N., Sachsenheimer, T., Gin, E., Wdowik, S., Lohmann, I., Wieland, F., Hofer, T., et al. (2011). A global circadian repressor controls antiphasic expression of metabolic genes in Neurospora. Molecular Cell 44, 687-697.

Hirota, T., Lee, J.W., Lewis, W.G., Zhang, E.E., Breton, G., Liu, X., Garcia, M., Peters, E.C., Etchegaray, J.P., Traver, D., et al. (2010). High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIalpha as a clock regulatory kinase. PLoS Biology 8, e1000559.

Zhang, E.E., Liu, A.C., Hirota, T., Miraglia, L.J., Welch, G., Pongsawakul, P.Y., Liu, X., Atwood, A., Huss, J.W., 3rd, Janes, J., et al. (2009). A genome-wide RNAi screen for modifiers of the circadian clock in human cells. Cell 139, 199-210.

Hirota, T., and Kay, S.A. (2009). High-throughput screening and chemical biology: new approaches for understanding circadian clock mechanisms. Chemistry & Biology 16, 921-927.

Hirota, T., Lewis, W.G., Liu, A.C., Lee, J.W., Schultz, P.G., and Kay, S.A. (2008). A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta. PNAS 105, 20746-20751.